Endocrine Abstracts

By 2008, we1 and others had established that excess body mass index (BMI), as an approximation of general body adiposity and excess calorie intake, is associated with increased risk of several cancer types. These associations exist for both common (colon, endometrial, post-menopausal breast cancers, oesophageal adenocarcinoma) and less common malignancies (thyroid cancer, non-Hodgkin lymphoma). Given the plausibility of the biological explanations (including insulin...

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BACKGROUND We examined the relationship between cigarette smoking exposure and serum IGF-I, IGF-II, IGFBP-2, and IGFBP-3 levels in a broad-based population, as both smoking and changes in the IGF/IGFBP system have been implicated as risk factors for common epithelial cancers.METHODS Blood was collected from 442 unselected individuals (M, 232: F, 210) attending the Flexi-Scope colorectal cancer screening trial. All individuals were healthy and aged 55-64...

Background: A polymorphism of the GHR gene, deletion of exon 3 (d3 GHR), has been associated with improved growth response to GH in some studies. We investigated the effect of this polymorphism across several diagnoses, evaluating parameters of growth outcome from a single institution (Manchester) and combined these with those derived from the literature using meta-analytical approaches.Methods: GHR genotype was assessed by PCR and related to clinical an...

Background: Insulin-like growth factor 1 (IGF1) plays a central role in metabolism and growth regulation. High IGF1 levels are associated with an increased risk of cancer, low IGF1 levels with increased risk for cardiovascular disease. We hypothesized that the relationship between circulating total IGF1 levels and mortality is U-shaped.Methods: We performed a systematic review searching PubMed, EMBASE, Web of Science, Cochrane Library (1985 to September ...